Pharma & Biotech
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Madrigal Pharmaceuticals Expands As Breakthrough Drug Fuels Growth
West Conshohocken’s Madrigal Pharmaceuticals is relocating its headquarters to accommodate rapid expansion, reports John George for The Philadelphia Business Journal. The creator of the first FDA-approved oral treatment for MASH has begun transitioning into three floors of Keystone’s 1K1 building on Conshohocken State Road. The new 54,000-square-foot space is an 86% increase from its Four…
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Nature Science Journal: Baby KJ in Clifton Heights Helped Shaped Medicine in 2025
A Clifton Heights infant named KJ Muldoon has made Nature Science Journal’s top 10 list of people who helped shape medicine in 2025, thanks to a frontline gene-editing treatment he received, writes Sarah Gantz for The Philadelphia Inquirer. CHOP and Penn are researching how to make his treatment available to more patients. KJ received international…
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Yardley-Based Jubilant Therapeutics Appoints Industry Veteran as New CEO
Jubilant Therapeutics, a Yardley-based biopharmaceutical company focused on cancer and autoimmune disease treatments, has named Daniel J. O’Connor to be its new CEO, writes John George for the Philadelphia Business Journal. O’Connor brings with him more than thirty years of executive experience in the life sciences industry. He previously led Ambryx Biopharma, a San Diego…
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Warrington’s Windtree Therapeutics Agrees to Buy Fintech Platform CommLoan
Warrington-based Windtree Therapeutics has agreed to acquire commercial technology finance business CommLoan in its latest attempt to diversify its revenue streams, writes John George for the Philadelphia Business Journal. The financial terms of the deal were not disclosed. According to the agreement, CommLoan, which operates a commercial real estate lending marketplace, will retain its key…
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Century Therapeutics Expands Pipeline with Type 1 Diabetes Drug Candidate
Philadelphia-based Century Therapeutics is broadening its drug development pipeline with a new candidate aimed at treating Type 1 diabetes, an autoimmune disease that affects 2 million people in the U.S., writes John George for the Philadelphia Business Journal. “There is a massive unmet need in Type 1 diabetes,” said Century CEO Brent Pfeiffenberger. “Type 2…
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CSL to Invest $1.5B in U.S. Growth Amid Restructuring and Local Layoffs
CSL, which has major operations in King of Prussia, announced plans to expand in the U.S., reports John George for the Philadelphia Business Journal. The Australian biopharmaceutical company plans to invest roughly $1.5 billion in its footprint over the next five years. Company leaders said the expansion will strengthen domestic manufacturing of plasma-derived therapies and…
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Warrington’s Windtree Therapeutics Calls Off Acquisition of Titan Environmental Services
Windtree Therapeutics, based in Warrington, has hit another setback in its efforts to expand beyond drug development, canceling its acquisition of Titan Environmental Services, writes John George for the Philadelphia Business Journal. Earlier this year, the company explored real estate and cryptocurrency opportunities, and most recently attempted to enter the waste-removal business. Windtree has now…
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Merck Invests $9.2B in Cidara to Boost Breakthrough Flu Drug
Merck is expanding its respiratory-health portfolio, the company announced in a press release. The pharmaceutical giant with significant operations throughout Montco announced a $9.2 billion agreement to acquire Cidara Therapeutics. The deal centers on CD388, a long-acting antiviral designed to prevent influenza in adults who face higher risks of complications. CD388 is currently in a…
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Orchestra Life Sciences Headquarters Moving from Canada to Philadelphia Navy Yard with Planned Expansion
Orchestra Life Sciences is moving its headquarters from Montreal in Canada, to the Philadelphia Navy Yard as it prepares for rapid growth, writes John George for the Philadelphia Business Journal. The firm, which supports pharmaceutical and biotechnology companies developing therapies for cancer and rare diseases, currently has more than 60 employees around the world and…
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Doylestown’s Pennsylvania Biotechnology Center to Expand with New Laboratory
The Pennsylvania Biotechnology Center of Bucks County is planning to add a new laboratory and office building on a lot across from its Doylestown campus, writes John George for the Philadelphia Business Journal. The 2.85-acre vacant property is owned by the Fred Beans Automotive Group and previously housed a swimming pool construction company. The Bucks…
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Merck Finalizes $10 Billion Acquisition, Expands COPD Treatment Portfolio
Pharmaceutical giant Merck, which maintains major operations in Montgomery County, has completed its $10 billion acquisition of Verona Pharma, writes the New Jersey Business and Industry Association. The acquisition strengthens its cardio-pulmonary treatment lineup with the addition of Ohtuvayre, a breakthrough therapy for chronic obstructive pulmonary disease (COPD). Verona Pharma now operates as a wholly…
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Amid Continued Financial Struggles, Warrington’s Windtree Therapeutics Shifts Focus
Following failed forays into real estate and crypto, Warrington-based Windtree Therapeutics is reinventing itself as a waste management and environmental services firm, writes John George for the Philadelphia Business Journal. This surprising pivot comes after the company’s struggle to find a partner for its drug candidate pipeline. “Capital is scarce out there, especially for cardiovascular…
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WSJ: GSK CEO Emma Walmsley to Step Down; Luke Miels to Lead Pharma Giant
Pharmaceutical giant GSK is preparing for a major leadership change that will resonate globally and locally, reports Elena Vardon and Adrià Calatayud for The Wall Street Journal. The London-based company, which has significant operations in Conshohocken, Upper Providence, and Upper Merion, announced that CEO Emma Walmsley will step down at the end of 2025. Chief…
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West Chester-Based Verrica Gets Medication Approval in Japan, Triggering $10M Milestone Payment
The regulatory approval of Verrica Pharmaceuticals‘ Ycanth in Japan has triggered a $10 million milestone payment to the West Chester-based company by its overseas partner, Torii Pharmaceutical, writes John George for the Philadelphia Business Journal. Verrica CEO Jayson Rieger said that the dermatology therapeutics company expects to receive the payment within the next several weeks…
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King of Prussia’s SEED Therapeutics Pioneers “Molecular Glue” Cancer Treatments
King of Prussia’s SEED Therapeutics is tackling one of medicine’s toughest challenges, writes Holly Quinn for Technical.ly. The biotech startup is treating diseases driven by proteins that current drugs can’t reach. The company is pioneering “molecular glues,” tiny drug molecules that fasten harmful proteins to a cell’s natural disposal system. Once tagged, the proteins are…
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Commonwealth Secures $4.1M from Pharma Company to Expand Bucks Operations
The Commonwealth has secured a $4.1 million investment from Levittown-based Apozeal Pharmaceuticals for the expansion of its Bucks County operations. The Shapiro Administration is supporting the drug manufacturer’s project with a $1.1 million state investment. The expansion will create at least 70 new, high-quality jobs over the next three years and ensure retention of 22…
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Merck’s Oral Cholesterol Therapy Offers Easier Alternative to Injections
Merck, the pharmaceutical giant with multiple locations across Montco, is reporting success with a new oral cholesterol drug, according to Reuters. The drug, enlicitide decanoate, recently met its main goal in a late-stage trial by reducing LDL (bad cholesterol) levels, which is a major risk factor for heart disease. Merck anticipates patent losses for their…
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Audubon’s Globus Medical Wins $9.5 Million Settlement
Audubon’s Globus Medical has secured a major courtroom win, writes John George for the Philadelphia Business Journal. A federal jury awarded the Montco medical device maker $9.5 million in a patent dispute. The 2021 case alleged that Illinois-based Life Spine’s Prolift line of implants infringed on several Globus patents. The contested technology involves expandable spinal…
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